We are recruiting a highly motivated and collaborative Post-Doc/Staff Scientist position to establish an HDX pipeline in the Krogan lab at UCSF. The Krogan lab utilizes proteomic and genomic systems biology techniques to study disease areas, including cancer, infectious disease, cardiovascular disease, and psychiatric conditions.
The successful candidate will be experienced with mass spectrometry-based structural proteomic techniques, specifically HDX, and analysis of large datasets. Familiarity with mass spectrometer instrument operation and maintenance is preferred. A motivation to develop and optimize new structural proteomic technologies will be beneficial for this position.
Professor Nevan Krogan has a well-established team of young and talented scientist working from the world renowned University of California - San Francisco (UCSF) and J. David Gladstone Institutes, both based in San Francisco, California. The success of the Krogan lab has largely been based on collaborations with the world’s top scientists who have been brought together through three of our main initiatives: the Host Pathogen Map Initiative (HPMI), the Cancer Cell Map Initiative (CCMI) and the Psychiatric Cell Map Initiative (PCMI). The HDX structural studies will be integrated into the main lab and expected to contribute to overall goals of the various mapping initiatives.
Responsibilities and Duties:
- Manage, organize and develop HDX related projects in the Krogan lab, working collectively towards goals in the Krogan lab cell mapping initiatives.
- Operate and maintain lab instruments involved in HDX data acquisition.
- Analysis of HDX data.
- Communicate and share research findings through written and oral reports and weekly lab meetings (virtual attendance) with the Krogan Lab at UCSF.
Requirements:
- PhD in Chemistry, Biochemistry, Biophysics, Molecular Biology, or related field
- Hands on experience and technical expertise with HPLCs and mass spectrometers, particularly the Thermo Q Exactive and Thermo Lumos.
- Hands on experience with robotic sample preparation equipment (i.e. LEAP PAL system)
- Familiarity with HDX techniques and data analyses, including HDExaminer and HDX Workbench.
- Strong communication and writing skills.
- Highly collaborative with excellent organizational skills and the ability to prioritize effectively.
- Capable and interested in developing and optimizing new analytical pipelines.
A competitive annual salary will be decided based on University salary scale according to candidate’s work experience and qualifications.